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2 edition of influence of collagen matrix properties on the anisotropy of cortical bone modulus. found in the catalog.

influence of collagen matrix properties on the anisotropy of cortical bone modulus.

Ranjini Mathivanar

influence of collagen matrix properties on the anisotropy of cortical bone modulus.

by Ranjini Mathivanar

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Published by Brunel University in Uxbridge .
Written in English


Edition Notes

ContributionsBrunel University. Department of Materials Technology.
The Physical Object
Pagination121p. :
Number of Pages121
ID Numbers
Open LibraryOL19718355M

Anisotropic viscoelastic properties of cortical bone. The results indicate that the KWW1 process in the empirical equation represents the relaxation in the collagen matrix in bone and that the KWW2 process is related to a higher-order structure of bone that is responsible for the anisotropic mechanical properties of bone. Anisotropy of.   Bone tissue is a functionally and structurally graded system; 90 long bone is a good example. In the macroscopic view, its cross-section can be divided into external compact cortical bone Author: Lisha Zhu, Dan Luo, Yan Liu.

interfaces are thought to improve the fatigue properties of cortical bone by providing avenues for dissipation of energy during crack propagation.7 The bone matrix that comprises lamellar and woven bone contains another level of porosity on the order of 5 to 10 µm that is associated with the bone cells (see Fig. a, b, c). Osteocytes, the mostFile Size: KB. The collagen-crystal unit, referred to as a mineralized collagen fibril, has a key influence on the overall mechanical properties of bone and is needed as an input for multiscale models of bone. Thus, it is crucial to characterize its architecture and predict the resulting mechanical by:

In the treatment of bone non-unions, an alternative to bone autografts is the use of bone morphogenetic proteins (BMPs), e.g., BMP–2, BMP–7, with powerful osteoinductive and osteogenic properties. In clinical settings, these osteogenic factors are applied using absorbable collagen sponges for local controlled delivery. Major side effects of this strategy are derived from the Author: Kai Stuckensen, José M. Lamo-Espinosa, Emma Muiños-López, Purificación Ripalda-Cemboráin, Tania Lópe. Osteons should affect the mechanical properties of the cortex in several ways: by the replacement of highly mineralized bone matrix with less calcified material, by increasing cortical porosity, possibly by altering collagen fiber orientation, and by the introduction of cement line interfaces that have different mechanical properties.


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Influence of collagen matrix properties on the anisotropy of cortical bone modulus by Ranjini Mathivanar Download PDF EPUB FB2

The influence of collagen matrix properties on the anisotropy of cortical bone modulus. (Thesis) ' ' Mathinvanar R Publisher: Brunel University [] Metadata Source: The British Library Type: Thesis. Abstract. No abstract provided. Menu. Author: R Mathinvanar. The treatment of bone using various methods that alter or influences its properties provides a method to evaluate mechanisms of loading.

This study confirms the importance of anatomical orientation and bone matrix organization on the anisotropic properties of cortical bone in compression. influence of material’s anisotropy of elastic or/and plastic regimes on direction-dependent properties of cortical bone obtained by means of indentation such as elastic moduli and hardness as well as to study the size effect phenomenon.

To achieve this, a three-dimensional finite element model of micro-indentation was developed. It should be emphasizedCited by: 5. The influence of matrix anisotropy will be discussed in a forthcoming paper.

Strictly speaking, bone is a poroelastic material and therefore a relevant framework with which to study the effective behaviour of the medium is that presented by Cowin () who applied the classical Biot poroelasticity theory to study deformation driven fluid Cited by: Purpose: The purpose of this study is to investigate the effect of anisotropy of cortical bone tissue on measurement of properties such as direction-dependent moduli and hardness.

Anisotropy in the compressive mechanical properties of bovine cortical bone and the mineral and protein constituents. Anisotropy in the compressive mechanical properties of bovine cortical bone and the mineral and protein constituents.

Note that these ARs are lower than actual anisotropy in cortical bone since in the present work the bony matrix anisotropy has been neglected; the latter has a significant influence on cortical bone anisotropy, as was pointed out by Crolet et by: Thus, the size and shape of the bone, as well as the properties of the bone tissue influence structural properties.

In contrast to the structural behavior, the material behavior, or material properties, of bone tissue is independent of the specimen geometry. However, a deeper comprehension of bone anisotropy could help understand the basic mechanical properties of mouse cortical bone.

The aim of this study is to shed light on the micromechanical properties along the longitudinal and transverse directions in the mouse femoral shaft and to determine a relationship between by: 9.

properties of bone, such as the post-yield deformation and work to fracture [5,12,13,2S]. Also, recent studies have demonstrated that age-related reductions in the toughness of bone correlates significantly with changes in the integrity of the collagen network in bone (e.g., collagen denaturation and cross-links) [29,30].

However,Cited by: elastoplastic material. In this study, a constitutive model of cortical bone considering anisotropic inelasticity and damage evolution was developed to predict injuries more accurately. The new model can satisfactorily represent mechanical properties of cortical bone including anisotropy of elastic modulus and yield stress withCited by: 1.

The influence of bone anisotropy with respect to principal stress/strain distribution on human femur external surface was accessed through the use of analytical and finite element approaches. The models results show that the principal angles at a medial path bone surface have a good correlation with human femur bone lamellae angles.

The bone properties is dependent on the morphology of bone, bone tissue properties and bone volume fraction in microscopic scale [1]- [4]. However, most of the studies of OI bone.

The mechanical properties of bone are affected by cross-linking of the organic matrix, which is an ultrastructural phenomenon. Ultrastructure and Microstructure and Effects On Mechanical Properties.

The mechanical properties of bone seen in the force displacement examples are expressions of the mechanical properties of the hard by: 1. Previous laboratory studies have suggested that changes in collagen may correlate significantly with bone mechanical properties.

The collagen matrix in bone has a highly hierarchical structure. The Type I collagen molecule is the basic building block of the matrix and is characterized by a triple helical structure of three amino acid chains. This study revealed the distinguished changes of preferential orientation of collagen and apatite and Young’s modulus in two different types of osteoporotic bones compared with the normal bone.

Little is known about the bone material properties of osteoporotic bones; therefore, we aimed to assess material properties in osteoporotic bones.

66 female Sprague–Dawley rats were by: 2. Cortical Bone –influence of porosity Elastic Modulus: From diverse studies (Schaffler and Burr,Carter and Hayes,Rice et al., ) we can consider that the elastic modulus is proportional to a power of the volume fraction: Cortical bone→ E (1 p) Trabecular bone→ E (1 p)2 Cortical and trabecular bone→ E (1 p)3File Size: 2MB.

In this study, heat-treated bone was examined as a collagen denatured model, and then four-point bending tests and impact tests were conducted to assess the role of the collagen matrix for mechanical properties of bone. Cortical bone specimens were obtained from the middiaphyses of bovine femurs and heat treated in an oven for 2 hours at Cited by: 3.

Human cortical bone contains two types of tissue: osteonal and interstitial tissue. Growing bone is not well-known in terms of its intrinsic material properties. To Cited by: 1. As an example, nanoindentation-derived modulus corresponded well to macroscopic modulus of bovine cortical bone when anisotropy of the matrix modulus and porosity was included in its calculation (Hengsberger et al., ).

Without accounting for the contribution of porosity to mechanical behavior, we still found that some RPI properties Cited by:. Collagen is the principal structural component of bone matrix, accounting for about 1/3 of mineralized bone tissues.

1 During development, bone formation and growth rates are regulated by genetic and hormonal factors, and by external factors such as mechanical loading that interact to determine the final anatomy and strength of the skeleton. During this period, bone also changes in its Cited by: Figure 1: Development of collagen matrix properties with age (mean ± SD).

Mechanical properties (top), and biochemical evaluation of collagen and its cross-links (bottom) are shown. Significant differences are based on Mann-Whitney U-test (* pCollagen (nmol/mg) Modulus (MPa) 80 0 10 20 Bone elasticity ; Gallery.

Cortical bone of human adults is the focus of this webpage. Cortical bone, which is the dense outer shell of bones (level a on figure), is also called 'osteonal' bone because it is made of secondary osteons, a product of the remodeling process (10% of the skeleton may be replaced each year).

Cortical bone.